Abstract: The DeSci sector is experiencing a long winter. Can Pump.Science‘s new compound break through the FUD (Fear, Uncertainty, and Doubt) dilemma?

Previously, there was Pump.fun, which generated millions of dollars a day, and now there’s Four.Meme, which is promoted by CZ. The casino effect of on-chain launch platforms remains strong. On February 8th, the long-dormant DeSci (Decentralized Science) sector saw a resurgence with the announcement that the established project Pump.Science would launch a new platform next week. Following the news, $Rif and $Uro both surged by 20%. Earlier, Pump.Science co-founder Benjels had stated in an interview that 20 new compound tokens would be launched by Christmas 2024.

However, in reality, he delayed this action until now. Within three months, due to external factors such as interest rate cuts, Pump.Science’s official tokens $Rif and $Uro have fallen by over 95% from their market capitalization highs of 240 million and 140 million, respectively. During the same period, the DeSci financial project BIO, which launched on Binance, also saw a decline of around 90% from its market cap peak. The DeSci sector, promoted by figures like CZ and Vitalik, seems to be in a state of despair. It appears that this once highly anticipated new narrative, which was expected to drive further mass adoption, has now become something many want to avoid.

Will Pump.Science‘s new launch platform spark a renaissance for DeSci?

According to official documentation from the Pump.Science community, the process for the new launch platform is as follows:

①Users list a compound along with a token on the Pump.Science platform.

②Users can buy and sell tokens on the same Bonding Curve as Pump.fun to support the research of this compound. 79% of tokens are issued along the Bonding Curve. When the token’s market value reaches 303 Sol (with 85 Sol in circulation), the Bonding Curve closes. 82 Sol of liquidity will be moved to Meteora for trading, and 3 Sol will be used to pay for related worm experiment fees.

It is particularly important to note that Pump.Science’s new launch platform will implement a dynamic fee structure to prevent sniping bots and avoid automatic loopholes during the initial token sale. Specific measures include:

①Bot deterrence: The dynamic fee structure is specifically designed to reduce the likelihood of sniping bots making front-running trades.

②Early risks: The fees are extremely high (99.99%) during the first 150 slots (around 2 minutes), which will significantly reduce the number of tokens received by buyers.

③Monitoring activity: Between the 150th and 250th slots (2-4 minutes), the fees will quickly decrease.

Dynamic fee structure curve:

The white paper also states that all new compounds must allocate a certain share of tokens as an airdrop to the builders and holders of $Rif and $Uro. Undoubtedly, the launch of Pump.Science’s new token launch platform is a grand-scale “self-rescue.” The sluggish DeSci sector urgently needs new attention hotspots and wealth-generating effects. At present, hunters on the Solana chain have been lost for too long in the numerous AI Agent and celebrity coins, leaving them exhausted both mentally and physically. Meanwhile, CZ’s prominent token promotions on the BSC chain have diverted attention. In this crisis-laden environment, can the DeSci fever of $Rif and $Uro be reignited to turn the situation around? With the arrival of new compounds, new developers, and new attention influx, can more DeSci gameplay be activated to bring in fresh vitality? Three months after the DeSci project made a grand announcement, the sector now faces a critical juncture to determine whether it will experience a renaissance or fade into obscurity.

Over-subscribed refund of 90%, $Pain-style presale of new compound EGS “full-scope layout” sparks discussion

At 3:19 AM on February 9th, Pump.Science’s official Twitter commented on its upcoming compound project $EGS @EGCGxSFN, stating, “Earning trust is the most admirable thing.” A look through Twitter reveals that Pump.Science’s new compound project $EGS unexpectedly opened a 24-hour presale window on the morning of February 7th. On-chain data shows that the presale wallet address for $EGS raised 1,223 Sol before block height 319172095. What is even more noteworthy is that the project announced on Twitter that it would refund 91.87% of the raised funds, leaving only 100 Sol for token issuance and liquidity support. This “over-subscribed high refund” strategy is reminiscent of the popular $pain project, but the refund behavior and ratio set a precedent for DeSci projects. The original tweet from the EGS project team reads: “24 hours, no marketing, no whales, we proved trust in science.” They also announced that EGS would launch with a 100k market cap, rewarding DeSci’s diamond hands, with the effective payments made during the presale having already earned approximately three times the profit.

EGS stands for Epigallocatechin Gallate and Sulforaphane. EGCG, the core active ingredient in green tea, is known as the “King of Antioxidants” for its ability to activate the AMPK pathway, suppress cell aging, and remove free radicals to reduce oxidative damage. Studies have shown that EGCG can extend the lifespan of model organisms such as nematodes and fruit flies by up to 20%. Its mechanisms include inhibiting pro-inflammatory factors, enhancing mitochondrial function, and possibly delaying telomere shortening through epigenetic regulation. Sulforaphane, derived from cruciferous vegetables like broccoli, is known as the “cellular guardian.” It activates the Nrf2 pathway to significantly enhance cellular antioxidant capacity. Experiments have confirmed that Sulforaphane can extend the lifespan of mice by about 15%, with key roles in promoting autophagy to eliminate aging cells, repairing DNA damage, and inhibiting chronic inflammation associated with aging (such as the NF-κB pathway). Both compounds work synergistically to delay aging through multiple targets, making them among the few natural compounds with clinical translational potential for longevity.

Clearly, the new compound follows the IP monetization logic of $Rif and $Uro and reduces risk through the high refund of presale funds, which is the “low barrier, high odds” story that DeSci desperately needs. However, with such a topic-driven presale gameplay combined with DeSci’s narrative of “trust in science,” will it align with the success of $Rif and $Uro after the launch on the new platform? The answer remains uncertain. Pump.Science co-founder Benjels candidly stated, “The problem with DeSci is that the narrative is grand, but the implementation is difficult.” “Users want to support science while seeking speculative gains, and balancing the two is key.” In today’s market, where price pumps are seen as justified, the single narrative of decentralized science has proven unable to gain market acceptance. The path to DeSci’s renaissance remains long and challenging, requiring more attention-grabbing gameplay to capture sensitive attention within the community. Let’s hope that this time, Pump.Science’s new compounds can bring new growth to the beleaguered DeSci sector, while also delivering both financial and spiritual comfort to the DeSci diamond hands still holding on, as promised in their tweet.

Appendix: Pump.Science New Compounds Overview

-Punicalagin & Berberine: Punicalagin, a powerful antioxidant and anti-inflammatory compound found in pomegranates; Berberine: an AMPK activator that helps regulate blood sugar and improve metabolic health. Together, they support cardiovascular health and anti-inflammatory pathways, complementing the metabolic effects of Berberine.

-Resveratrol & Berberine: Resveratrol, a polyphenol, activates sirtuins, enhances mitochondrial efficiency, and mimics calorie restriction effects; Berberine: an AMPK activator that regulates blood sugar and improves metabolic health. Together, they activate both AMPK and sirtuins, potentially enhancing longevity, metabolic control, and cell repair.

-Ginsenoside Rh2: Ginsenoside Rh2, a bioactive compound from ginseng, with anti-cancer, neuroprotective, and anti-inflammatory properties.

-Aspalathin & Caffeine: Aspalathin, a bioactive flavonoid found in Rooibos tea, with antioxidant and blood sugar-lowering effects; Caffeine, a stimulant, enhances mental and physical energy. Together, Aspalathin counteracts the potential negative impact of caffeine on blood sugar and stress hormones, providing a more balanced stimulant response.

-Gossypol & Catechin Hydrate: Gossypol, a polyphenol with potential anti-cancer and metabolic benefits; Catechin hydrate, a catechin similar to EGCG, with strong antioxidant properties. Together, these compounds regulate cellular stress responses and enhance metabolic efficiency.

-Biotin & Berberine: Biotin, essential for fatty acid metabolism, glucose regulation, and skin health; Berberine, a metabolic regulator that enhances insulin sensitivity. Together, Biotin complements Berberine’s effects by improving lipid metabolism and enhancing mitochondrial function.

-Urolithin A & EGCG: Urolithin A, a metabolite derived from pomegranate, promotes mitophagy (recycling damaged mitochondria); EGCG, a green tea catechin, with strong antioxidant and anti-inflammatory properties. Together, they support mitochondrial function and longevity pathways, potentially improving cellular energy efficiency.

-Berberine & Quercetin: Berberine, a metabolic regulator that enhances insulin sensitivity, lowers blood sugar, and supports cardiovascular health; Quercetin, a flavonoid with anti-inflammatory, antioxidant, and antiviral properties, promoting nutrient absorption. Together, Quercetin enhances the bioavailability of Berberine while complementing its metabolic effects, improving glucose regulation and mitochondrial function.

-Hesperidin & DHM (Dihydromyricetin): Hesperidin, a flavonoid found in citrus, improves blood circulation, reduces oxidative stress, and supports vascular health; DHM (Dihydromyricetin), used for liver protection, supporting alcohol metabolism, and neuroprotection. Together, these compounds regulate liver enzymes and inflammatory pathways, enhancing detoxification and metabolic recovery.

-EGCG: A green tea catechin, with strong antioxidant and anti-inflammatory properties.

-Caffeine: Caffeine, a stimulant, enhances energy, cognitive function, and endurance, supporting liver detoxification and reducing premature death.

-Artemisinin: Artemisinin, derived from sweet wormwood, with anti-malarial, anti-cancer, and anti-inflammatory effects.

Recently, as Binance Research published another article affirming the DeSci sector, BIO, Rif, and Uro all saw a 20% increase. It seems that the DeSci wave is about to rise again. Meanwhile, these compounds are also set to launch on the new Pump.Science platform. With such a broad range of tokens being launched, it’s important for everyone to continue focusing on high-quality tokens and carefully selecting projects that are serious about their work and capable of innovation. DYOR!

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